PRODUCTION OF CELL CONTAINING FOREIGN DNA INCORPORATED STABLY IN HIGH COPY NUMBER, PRODUCED CELL AND USE OF SAID CELL IN ORDER TO PRODUCING POLYPEPTIDE ENCODED BY FOREIGN DNA

摘要

An improved method, employing electroporation, for producing novel recombinant host cells characterized by stably integrated foreign DNA at high copy number. These recombinant host cells are useful in the efficient, large-scale production of recombinant proteins and polypeptides.