MONO, DI AND TRI(MONOCARBOXYALKYL)AMMONIO-UNDECAHYDRODODECABORATE(-1)

摘要

NEW MATERIAL:A compound of formula I (A is lower alkylene; M is H, an atom or group thereof giving a monovalent cation or 1/pmole of an atom or mixture thereof giving a p-valent cation; n is 1-3). EXAMPLE:A thermal neutron-capturing agent. Especially useful for monoclonal antibody method. USE:An ammonium group is introduced into sodium dodecahydrododecaborate of formula II to give sodium ammonio-undecahydrododecaborate of formula III. The compound of formula III is subjected to a sodium halide-removing reaction with a halogenated alkanoic acid ester of a formula X-A-COOR (X is halogen such as Cl or Br; R is lower alkyl) such as methyl chloroacetate. The ester bond of the reaction product is hydrolyzed under a week alkaline condition.