PURPOSE:An agent, containing 1-methyl-4,5-dihydroorotyl-histidyl-prolinamide as an active ingredient and useful for treating central nervous disorder, e.g. disturbance of consciousness, senile dementia, etc., and hardly causing side effect. CONSTITUTION:A remedy containing 1-methyl-4,5-dihydroorotyl-histidyl- prolinamide expressed by the formula or an acid addition salt thereof as an active ingredient. The compound expressed by the formula has improved arousal promoting action and pentobarbital anesthetic antagonistic action, is capable of remarkably activating acetylcholine neuron of hypothalamus, brain stem reticular formation, brain cortex and hippocampus and suitable as a remedy for disturbance of consciousness and senile dementia and further exhibiting increasing action on conductivity and excitability of spinal movement neuron membrane and usable for treating spinocerebellar deformity. The agent has relatively less side effect (TSH releasing action, etc.) and higher safety than TRH and various derivatives thereof.
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