Process for the preparation of ocmpuestos of macrolida.

摘要

S541 (LL-F28249) compounds of formula (I) CHEM [wherein R1 is a methyl, ethyl or isopropyl group; R2 is a hydrogen atom or a group OR5 (where OR5 is a hydroxyl group or a substituted hydroxyl group) and R3 is a hydrogen atom, or R2 and R3 together with the carbon atom to which they are attached represent C=0, C=CH2 or C=NOR6 (where R6 represents a hydrogen atom, C1-8 alkyl group or a c3-8 alkenyl group and the group C=NOR6 is in the E configuration); and R4 is a hydrogen atom or a methyl group] which comprises incubating a corresponding 5-keto compound in a suitable medium in the presence of a microorganism or an enzyme derived therefrom or a preparation derived from a microorganism containing the enzyme of interest capable of effecting the conversion .