METHOD OF 2-(TETRAHYDRO-2-FURFURYL)-3-(1-NAPHTHYL)-PROPANOIC ACID PREPARATION

摘要

Solution concerns the method of the preparation of 2-/tetrahydro-2-furfuryl/-3-/1-naftyl/propanoic acid of formula I by alkaline hydrolysis of dialkyl esters of 1-/tetrahydro-2-furyl/-3-/1-naftyl-2.2-propandicarboxylic acid of the general formula III, in which R means methyl or ethyl group and subsequent thermic decarboxylation of corresponding alkaline salts and/or of dicarboxylic acid of the general formula II, in which R1 means the atom of sodium, potassium, or hydrogen in mineral acid and in an aprotic solvent. The solution makes it possible to execute a one-step synthesis of the required substance of the formula I, without isolation of intermediate products. The substance of the formula I serves as an intermediate product in the preparation of pharmaceutical with vasodilatative and nootropic effects in human medicineIMAGE