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genes and their encoded proteins which regulate gene expression of interleukin-2 receptor and of human, lymfotrope retrovirus

机译:基因及其编码的蛋白,调节白细胞介素2受体和人淋巴细胞型逆转录病毒的基因表达

摘要

The present invention is directed to genes, termed Rpt-1 (regulatory protein T lymphocyte-1), which are expressed at higher levels by resting CD4+ helper/inducer T cells relative to activated CD4+ cells. The invention also relates to the proteins encoded by such genes, termed rpt-1 proteins, which regulate gene expression directed by the promoter region of the interleukin-2 receptor (IL-2r) alpha chain gene or by the promoter region of the long terminal repeat of human lymphotropic retroviruses such as the human immunodeficiency virus type 1 (HIV-1) human T cell leukemia virus (HTLV)-I, and HTLV-II. In particular, rpt-1 proteins down-regulate gene expression controlled by the promoter of the IL-2r alpha chain gene or by the promoter of the long terminal repeat of HIV-1. The proteins and nucleic acids of the invention have value in diagnosis and therapy of immune disorders such as AIDS. In a specific example of the present invention, an Rpt-1 gene and its encoded intracellular protein of approximately 41,000 daltons molecular weight are described. The rpt-1 protein is shown to be selectively expressed by activated CD4+ T cells, and to down-regulate gene expression of the IL-2r and the HIV-1.
机译:本发明涉及称为Rpt-1(调节蛋白T淋巴细胞-1)的基因,相对于活化的CD4 +细胞,其通过静息的CD4 +辅助/诱导T细胞以更高的水平表达。本发明还涉及由称为rpt-1蛋白的此类基因编码的蛋白,其调节由白介素2受体(IL-2r)α链基因的启动子区域或长末端的启动子区域指导的基因表达。人类淋巴逆转录病毒,例如人类免疫缺陷病毒1型(HIV-1)人类T细胞白血病病毒(HTLV)-I和HTLV-II的重复序列。特别是,rpt-1蛋白下调了IL-2rα链基因启动子或HIV-1长末端重复序列启动子控制的基因表达。本发明的蛋白质和核酸在免疫疾病例如AIDS的诊断和治疗中具有价值。在本发明的一个具体实例中,描述了一种Rpt-1基因及其编码的细胞内蛋白质,其分子量约为41,000道尔顿。 rpt-1蛋白被激活的CD4 + T细胞选择性表达,并下调IL-2r和HIV-1的基因表达。

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