MACROCYCLIC POLYAZA COMPOUNDS CONTAINING A 5- OR 6-RING RING, METHOD OF PREPARING THEREOF AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS

摘要

Macrocyclic compounds of the general formula I IMAGE in which @is a single or double bond, q is the numbers 0-5, A and B, which are identical or different, are each a straight-chain or branched alkylene group with 2 to 6 carbon atoms, D is a nitrogen, oxygen atom, the group =C=O, =NR2 with R2 being a hydrogen atom or a C1-C6-alkyl group, the group IMAGE with R3 being a hydrogen or halogen atom, a phenyl, a C1-C6-alkyl group which is optionally substituted by one or more phenyl and/or hydroxyl group(s), being the radical OR5 where R5 is a C1-C6-alkyl radical which is optionally substituted by 1 to 3 hydroxyl groups, being the substituent IMAGE where l is the numbers 0 and 1 and R6 and R7 are, independently of one another, hydrogen atoms, the radical R5, phenyl or benzyl radicals which are optionally substituted by 1 to 3 hydroxyl groups, or R6 and R7 are, together with the nitrogen atom, a saturated or unsaturated, 5- or 6-membered ring which optionally contains another nitrogen, oxygen, sulphur atom or a carbonyl group and which is optionally substituted by 1 to 3 radicals R5, or one of the substituents R6 or R7 is the radical IMAGE or being the substituent G where G is a second macrocycle which is bonded via a direct bond, a bis(carbonylamino) group (-NH-CO-CO-NH-) or via a C1-C20-alkylene group which optionally carries at the ends carbonyl ( CO) or carbonylamino (-NH-CO-) groups or oxygen atoms and optionally contains one or more oxygen atom(s), Z-, acyl- or hydroxyacyl-substituted imino groups or one to two C-C double and/or C-C triple bonds, and has the general formula II IMAGE in which D1 has the same meaning as D with the exception that D1 does not contain the substituent G, or is the radical -CH-, =C- or -N- and F1 has the same meaning as F with the exception that F1 does not contain the substituent G, or is the radical -CH-, or =C-, E is a nitrogen, sulphur, oxygen atom, the IMAGE or NR4 group with R4 being a hydroxyl group, being R2 or being an optionally hydroxylated or carboxylated C1-C6-alkyl group, F is (-CHR8-)n or (=CR8)n with n being the numbers 0 or 1 and R8 being R1 or G, R1 is a hydrogen or halogen atom or a C1-C6-alkyl group, Z is a hydrogen atom or the group -CH2COOY with Y being a hydrogen atom and/or a metal ion equivalent of an element of atomic numbers 21-29, 31, 32, 37-39, 42-44, 49 or 57-83, with the proviso that at least two of the substituents Z are the radical -CH2COOY and that the macrocyclic compound of the general formula I does not contain more than one radical G, and the salts thereof with inorganic and/or organic bases, amino acids or amino amides are valuable diagnostic and therapeutic agents.