METHOD FOR PRODUCING NEW BIOLOGICALLY ACTIVE MATERIALS NOTATED LL-F 28249 AND VETERINARY PREPARATIVES SAID MATERIALS AS ACTIVE AGENTS AS WELL AS NEMATOCIDE INSECTICIDE AND ACARICIDE PREPARATIVES CONTAINING SAID MATERIALS AS ACTIVE AGENTS

摘要

The present invention relates to novel agents, to their production by fermentation, to methods for their recovery and concentration from crude solutions, to processes for their purification and to pharmaceutically and pharmacologically-acceptable salts thereof. Also, this invention relates to methods and compositions for the control and prevention of helmintic, arthropod ectoparasitic and acaridal infections, in warm-blooded animals, such as meat-producing animals, and poultry, by administering to said animals a therapeutically or prophylactically-effective amount of new agents designated LL-F28249 alpha , beta , gamma , delta , epsilon , zeta , eta , theta ,@, kappa , lambda , mu , nu , and omega or mixtures thereof. The invention also relates to methods for the control of plant nomatode infestations and other insecticidal activities. These novel agents are produced via a controlled condition microbiological fermentation using Streptomyces cyaneogriseus ssp. noncyanogenus, designated LL-F28249 and having deposited accession number NRRL 15773.