首页> 外国专利> compounds and pharmaceutical preparations with anticholinergic, anti histaminische, hoeststillende and / or analgesic effect and method for the preparation of the compounds.

compounds and pharmaceutical preparations with anticholinergic, anti histaminische, hoeststillende and / or analgesic effect and method for the preparation of the compounds.

机译:化合物和具有抗胆碱能,抗组织性,霍斯坦汀和/或镇痛作用的药物制剂以及制备该化合物的方法。

摘要

Novel substituted quinolizidine and indolizidine derivatives of the general formula: IMAGE where A denotes a phenyl or 2-thienyl group and n denotes an integer of 3 or 4, and their acid addition salts and quaternary salts which have a strong antiacetylcholinergic action coupled with decreased side effects and can be prepared by dehydration of a compound of the general formula: IMAGE where A and n have the abovementioned meanings, and if appropriate by reaction of the resulting compounds with the appropriate acid or quaternising agent.
机译:通式为的新型取代的喹喔啉和吲哚并咪唑衍生物,其中A表示苯基或2-噻吩基,n表示3或4的整数,其酸加成盐和季盐具有较强的抗乙酰胆碱能作用,并与可以通过使通式:的化合物脱水来制备,其中A和n具有上述含义,并且如果合适的话,通过使所得化合物与合适的酸或季铵化剂反应来制备。

著录项

  • 公开/公告号NL186006B

    专利类型

  • 公开/公告日1990-04-02

    原文格式PDF

  • 申请/专利号NL19780005272

  • 发明设计人

    申请日1978-05-16

  • 分类号C07D455/02;A61K31/445;

  • 国家 NL

  • 入库时间 2022-08-22 06:18:27

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