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PEPTIDES AND MULTIMERS IMMUNOLOGICALLY RELATED TO CIRCUMSPOROZOITE PROTEIN; VACCINES AGAINST PLASMODIUM FALCIPARUM-INDUCED MALARIA
PEPTIDES AND MULTIMERS IMMUNOLOGICALLY RELATED TO CIRCUMSPOROZOITE PROTEIN; VACCINES AGAINST PLASMODIUM FALCIPARUM-INDUCED MALARIA
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机译:与环孢子蛋白免疫相关的肽和多聚体;恶性疟原虫诱导的疟疾疫苗
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摘要
A mixture of the synthetic peptide compounds of the formulas: Formula (I) Tyr-Gly-Gly-Pro-Ala-Asn-Lys-Lys-Asn-Ala-Gly-OH, Formula (II) Asp-Glu-Leu-Glu-Ala-Glu-Thr-Gln-Asn-Val-Tyr-Ala-Ala-NH2, and Formula (III) Tyr-Ser-Leu-Phe-Gln-Lys-Glu-Lys-Met-Val-Leu-NH2, and compositions thereof, induces antibodies against the late stages of Plasmodium falciparum malaria and provides protection against infection with this parasite, thus providing a synthetic malaria vaccine for Plasmodium falciparum induced malaria. A synthetic protein copolymer vaccine, polymerized from a monomer which is a hybrid of formulas (II), (III) and (I), and which also includes the (Asn-Ala-Asn-Pro) sequence of the CS protein between formulas (II) and (III) and Formulas (III) and (I) of the monomer, has been shown to provide safe and complete self-limiting protection in human volunteers against the asexual blood stages of P. falciparum induced malaria.
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