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METHOD FOR MANUFACTURING NEW DERIVATIVES OF QUINOLE
METHOD FOR MANUFACTURING NEW DERIVATIVES OF QUINOLE
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机译:制造奎诺尔新衍生物的方法
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摘要
Quinolone sulphonates of formula I CHEM in which R1 is lower alkyl; R2 is lower alkyl; and R3, R4 and R5, which may be the same or different, are hydrogen, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulphinyl, lower alkylsulphonyl, halo, halogenated lower alkyl, halogenated lower alkoxy, cyano, phenyl or phenyl substituted by 1 or 2 groups independently selected from lower alkyl, lower alkoxy and halo, have antihypertensive activity. Processes for preparing compounds of formula I and pharmaceutical compositions containing them are described. Compounds of formula I are also indicated for use in the treatment of heart failure and ischaemic heart disease.
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机译:式I 的喹诺酮磺酸盐,其中R1为低级烷基; R 2是低级烷基; R3,R4和R5可以相同或不同,它们是氢,低级烷基,低级烷氧基,低级烷硫基,低级烷基亚磺酰基,低级烷基磺酰基,卤素,卤代低级烷基,卤代低级烷氧基,氰基,苯基或被苯基取代的苯基。 1或2个独立地选自低级烷基,低级烷氧基和卤素的基团具有抗高血压活性。描述了制备式I化合物的方法和包含它们的药物组合物。还指出了式I化合物可用于治疗心力衰竭和局部缺血性心脏病。
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