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delta crystalline form, stable, anhydrous of hydrochloride of prazosin and new process for the preparation of the delta crystalline form
delta crystalline form, stable, anhydrous of hydrochloride of prazosin and new process for the preparation of the delta crystalline form
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机译:δ晶型,稳定,无水的哌唑嗪盐酸盐和制备δ晶型的新方法
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摘要
Anhydrous, stable, crystalline delta -form of prazosin hydrochloride, having an infrared spectrum in potassium bromide of FIG. 1 having the following sharp absorption bands at 7.95 mu , 13.3 mu , and a triplet at 9.95 mu and the x-ray diffractogram of FIG. 2 having sharp bands in 10.5 DEG , 12.0 DEG , 16.9 DEG , and doublets in 24.5 DEG and 26.5 DEG . The delta -form of prazosin hydrochloride is prepared by removing the water of crystallization of prazosin hydrochloride hydrate by azeotropic distillation with selected organic solvents having a boiling point in the range of 55 DEG -160 DEG C. The delta -form of prazosin hydrochlorie is useful as a hypotensive agent.
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