Process for the preparation of novel 7 beta-(fluorinated methylthio)-acetamido-7 alpha-methoxy-3-(1-(2- hydroxyalkyl)-1H-tetrazol-5-yl)thiomethyl-1-dethia-1-oxa- 3-cephem-4-carboxylic acid derivatives

摘要

7 Beta-(fluorinated methylthio)-acetamido-7 alpha-methoxy- 3-(1-(2-hydroxyalkyl)-1H-tetrazol-5-yl)-thiomethyl-1- dethia-1-oxa-3-cephem-4-carboxylic acid derivatives of the general formula I in which R is FCH2- or F2CH-, R1 is optionally protected 2-hydroxyalkyl, and R2 is hydrogen, a light metal atom or a carboxyl protective group, have antibacterial activity. They are obtained by reacting a 7 beta-(fluorinated methylthio)-acetamido-7 alpha-methoxy-3-halomethyl-1- dethia-1-oxa-3-cephem-4-carboxylic acid derivative with 1- (2-hydroxyalkyl)-1H-tetrazol-5-ylthiol. IMAGE