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USE OF A LOW AFFINITY-HEPARIN FRACTION IN CONJUNCTION WITH t-PA FOR THROMBOLYTIC THERAPY
USE OF A LOW AFFINITY-HEPARIN FRACTION IN CONJUNCTION WITH t-PA FOR THROMBOLYTIC THERAPY
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机译:低亲和力肝素分数与t-PA联合用于溶栓治疗
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摘要
A composition for thrombolytic therapy includes a tissue-type plasminogen activator (t-PA) and a low affinity heparin fraction. The composition is administered intravenously to allow the t-PA to dissolve blood clots while the low affinity heparin fraction prevents reocclusion without the harmful side effects observed for unfractionated heparin, such as, stimulation of and interference with t-PA activity in the circulatory system, as well as, interference with fibrinolytic activity which can cause hemorrhaging in the mammalian circulatory system.
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