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(EX VIVO)-EFFECTOR CELL ACTIVATION FOR TARGET CELL KILLING.
(EX VIVO)-EFFECTOR CELL ACTIVATION FOR TARGET CELL KILLING.
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机译:(EX VIVO)-靶细胞杀伤的有效细胞激活。
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摘要
A method and composition for killing target cells is disclosed. The method utilizes ex vivo IL-2 activation of leucocyte effector cells and arming the activated leucocyte effectors with monoclonal antibodies whose Fc portions bind to the IL-2-activated effectors and whose paratopic portions immunoreact with an epitope expressed on the surfaces of the target cells. The composition contains a cytolytic amount of the armed, IL-2-activated effector cells dispersed in an aqueous physiologically tolerable diluent medium.
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