MONOCLONAL ANTIBODY AGAINST THE RGD-DIRECTED ADHESION RECEPTOR OF ENDOTHELIAL CELLS.

摘要

A monoclonal antibody that immunoreacts with ECr, the RGD-directed adhesion receptor found on the surface of both endothelial and melanoma cells, is disclosed. Methods whereby that monoclonal antibody can be used to inhibit the ability of cells that contain the adhesion receptor to adhere to a subendothelial matrix composed of vitronectin, fibrinogen or von Willebrand factor are also disclosed. Further disclosed are diagnostic systems and methods for assaying for ECr in a body sample using the antibody of the invention.