derivatives of morpholinyldaunorubicin and morpholinyldoxorubicin, a procedure for their production and the use of the same as anti-cancer agents

摘要

A group of new daunorubicin and doxorubicin derivatives is disclosed. These materials have the formula IMAGE (I) wherein R is CO-CH3 or CHOH-CH3 in the case of daunorubicin derivatives or CO-CH2OH or CHOH-CH2OH in the case of doxorubicin derivatives; X is O or NH; and A is either a cyano group (CN) or a hydrogen, subject to the limitation that when X is O, A must be a cyano group. When A is hydrogen, these compounds can exist as acid addition salts, as well. Derivatives of these compounds are disclosed as well.