AMINO ACIDS AND PEPTIDES HAVING MODIFIED TYROSINE RESIDUE, PREPARATION THEREOF AND APPLICATION AS MEDICAMENTS

摘要

These compounds are represented by formula I, wherein R 1 to R 2 = H, C 1 -C 8 alkyl, C 3 -C 7 cycloalkyl or aromatic; (When R1 = H, R2 may be amine protecting group, amino acid residue or peptide fragment, R1 and R2 may form with N a 5-7 membered ring); A = carbonyl or methylene; W = hydroxy, phenoxy, C 1 -C 8 alkoxy, phenoxy (C 1 -C 8) alkyl, amino, (C 1 -C 8) alkylamino, di (C 1 -C 8) alkylamino, (when A = carbonyl, W = amino acid residue or peptide fragment); Y = -OSO 2 OR 3 II, -OPO (OR 3) 2 III, - (CH 2) m -SO 2 OR 3 IV or - (CH 2) m -PO ( OR3) 2 V [R3 = H, C1-C8 alkyl; m = 1 to 4]; Z = cyclohexane, pyridyl or phenyl; n = 0 to 4; provided that when Y = II or III, -A-W is other than a sequence composed of natural amino acids. They have antipsychotic properties, an effect facilitating memory processes, analgesic properties; they are useful as anorectics, and they have effects stimulating the intestinal motility. BR/ (CF DRAWING IN BOPI) BR/ / P