Evidence for the development of AIDS (the second contamination is obligatory, the first is necessary for the creation of antibodies): vaccination by tolerance against the virus is the outcome

摘要

It is demonstrated that the development of AIDS must necessarily have at least two contaminations. It is concluded that, during the first contamination, with high concentrations, the AIDS virus (HIV), in choosing macrophages as its target, cannot create new particles in the body and is eliminated. During the development of the immune response to the viral particles, antibodies, partly representing autoantibodies to the immunologically important proteins of the host, are produced. These (auto)antibodies are the agents which cause the observed dysfunction of the immune system. Antibodies to the envelope proteins are normally created strictly after elimination of the (infectious) viral particles. In this stage, the virus cannot be transmitted by insects. During the second contamination, which is obligatory for the development of AIDS, the virus enters the T lymphocytes with the assistance of the antibodies to these envelope proteins, creating a syncytium and consequently destroying the T4+ cells. This phase is rapid, and only a few viral particles can cause AIDS. On account of the small dose of virus needed during this step, contamination can be transmitted by insects. Babies must develop AIDS with virus-contaminated milk. On the basis of the above evidence, I have shown that the groups of AIDS patients (acute primary infectious syndrome, asymptomatic infection, persistent generalised lymphadenopathy) represent a misleading mixture of cases. Consequently, the two classifications existing today, CDS and Walter Reed, are wrong in principle because there is no progression to AIDS without a second contamination, and the dogma: "more than 75-90% of infected individuals will develop AIDS" (Brit. J. Med. 297, 1067, 1988), currently accepted by all the world's scientists and doctors, is meaningless. Consequently, vaccination with the novel principle, which eliminates the specific B and/or T lymphocyte clones against the proteins of the viral envelope, is proposed.