6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4- hydroxypyran-2-one inhibitors of cholesterol biosynthesis

摘要

Certain trans-6-[[(substituted)pyridin-3-yl]-alkyl- and alkenyl] tetrahydro-4-hydroxypyran-2-ones and the corresponding ring- opened acids derived therefrom are potent inhibitors of the enzyme 3- hydroxy-3- methylglutaryl-coenzyme A reductase (HMG-CoA reductase) and are useful as hypocholesterolemic and hypolipidemic agents.