Synthetic process for the preparation of N,N dimethyl glycine (DMG)

摘要

A process for synthetically producing N,N-Dimethyl Glycine, commonly referred to as DMG, through the neutralization of N,N-dimethyl glycine sodium salt with sulfuric acid wherein the N,N-dimethyl glycine sodium salt is prepared by reacting formaldehyde, sodium bisulfite, dimethyl amine, and sodium cyanide followed by agitation with caustic soda beads. Through the preparation and intermediate steam distillation and isolation of N,N-Dimethylamino acetonitrile. The nitrile solution is subjected to caustic hydrolysis then is subsequently neutralized leaving DMG in methanol extraction solvent. The methanol is removed in an azeotropic distillation step to produce DMG in a high yield, low cost and excellent quality.