MEDICAMENT CONTAINING SWELLFISH POISON AS PHARMACEUTICALLY EFFECTIVE COMPONENT, ITS PREPARATION AND EXTRACTION OF SAID SWELLFISH POISON

摘要

PURPOSE: To provide a drug, comprising a toxin extracted from the ovary of a globefish as an active ingredient and effectively usable for a biochemical reagent used in genetic engineering, a therapeutic agent for arrhythmia, an analgesic agent, an insecticide, etc. CONSTITUTION: The ovary of a globefish is dipped in a liquid to extract a toxin in the ovary into the liquid. The extracted toxin is then centrifuged and subsequently filtered to remove an unrequired solid. Thereby, a primary supernatant is obtained and heated at 80 deg.C to coagulate proteins until an albumenlike state of an egg attains. The heated material is filtered to remove the proteins. A secondary supernatant is prepared and permeated through a filter to trap the toxin in the filter. The filter trapping the toxin is then washed with an acetic acid solution to produce the acetic acid solution containing the toxin. The resultant solution is regulated to a weakly alkaline state to precipitate and recover the toxin.