CASCADE POLYMER CONTAINING COMPLEX-FORMING LIGAND, PREPARATION THEREOF AND DRUG CONTAINING SAID CASCADE POLYMER

摘要

PURPOSE: To obtain a complex, comprising a nitrogen-containing cascade polymer having a complexing ligand and ions, etc., of specific elements and suitable for producing an NMR diagnostic agent and an X-ray diagnostic agent. CONSTITUTION: This cascade polymer comprises a complexing ligand, as necessary, at least 5 ions of an element of atomic numbers of 21-29, 39, 42, 44 or 57-83 and, as necessary, a cation of an inorganic and/or an organic base, an amino acid or an amino acid amide and is represented by formula I [A is an N-containing cascade nucleus of a basis multiplicity (b); S is a repeating unit; Z1 and Z2 are each represented by formula II for the first to the penultimate generation; Z1 is H, carboxyl, sulfo group, OH, a residue, etc., of a chelating agent or a complex K for the last generation; 96-100% of the total Z2 content is the residue of K; 4-0% thereof is V' (V' is one functional group or a residue V, capable of bonding through the functional group and having a bio- or a macromolecule; V is a substitutable alkylene); (b) is 1-50; (s) is 1-3].