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CREATINEAMIDINOHYDRASE, NOVEL PLASMID, MICROORGANISM, PRODUCTION OF ENZYME AND MEASUREMENT OF CREATINE CONTENT
CREATINEAMIDINOHYDRASE, NOVEL PLASMID, MICROORGANISM, PRODUCTION OF ENZYME AND MEASUREMENT OF CREATINE CONTENT
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机译:芥子酰胺酶,新型疟原虫,微生物,酶的产生和芥子碱含量的测定
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摘要
A creatine amidinohydrolase in which the alanine in position 109 of the amino-acid sequence of the wild-type enzyme is replaced by valine and, where appropriate, additionally one or more other amino acids of the wild-type enzyme are mutated is more stable than the wild-type enzyme and is therefore more suitable for reagents. It is prepared by bringing about the expression, by known genetic engineering methods in a suitable expression system, of a recombinant DNA which contains a creatine amidinohydrolase gene which contains the deoxyribonucleotide T in position 326 of the natural gene in place of C.
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