METHOD FOR IMPROVING PHARMACOLOGICAL ACTIVITY OF PHELLODENDRI BARK

摘要

PURPOSE:To improve pharmacological activity by treating Phellodendri bark with an extruder. CONSTITUTION:Phellodendri bark which is used as a human stomachic agent, medicine for controlling intestinal function, astringent agent anti-inflammatory agent, etc., or preventive and treating agent for Haemophilus infectious disease of animals, such as pig, is regulated to about 0.05 to 5mm size, fed to an extruder and treated at 50 to 200 deg.C, preferably 100 to 150 deg.C temperature while adding 0.03 to 2l water based on 1kg dried Phellodendri bark. The dose thereof administered to humans or animals expressed in terms of the crude drug-parent chemical per 1kg body weight per day is preferably within the ranges of 0.001 to 10g for oral administration to the humans and 0.01mg to 1g for parenteral administration to the humans or 1mg to 10g for oral administration to the animals and 0.01mg to 1g for parenteral administration to the animals for several to several tens days.