CRYSTALLINE 2',3'-DIDEOXYINOSINE MONOHYDRATE, 2',3'-DIDEOXY-2',3'-DIDEHYDROTHIMIDINE MONO- HYDRATE AND 2',3'-DIDEOXY-2'-FLUOROINOSINE HEMIHYDRATE WHICH ARE ANTIVIRAL, HAVE WATER SOLUBILITY AND ARE STABLE

摘要

NEW MATERIAL: Highly water soluble, stable, crystalline salts; a salt of 2',3'- didoxy-2',3'-didehydrothymidine of formula I, a salt of 2',3'-didoxyinosine of formula II and a slat of 2',3'-dideoxy-2'-fluoroinosine of formula III, wherein X is an organic or inorganic cation. ;EXAMPLE: Sodium salts of compounds of formulae I, II or III. ;USE: An antiviral active agent (including anti-retroviral activity). ;PREPARATION: 2',3'-Dideoxy-2',3'-didehydrothymidine, 2',3'-dideoxyinosine or 2',3'-dideoxy-2'-fluoroinosine is reacted with a base which provides the desired organic or inorganic cation in an inert aqueous medium and the desired salt is crystallized from the solution to obtained the objective compounds of formula I, II or III.;COPYRIGHT: (C)1991,JPO