METHOD OF OPTICALLY ACTIVE TRANS-(-)-1 BETA-ETHYL-1 ALPHA-HYDROXYMETHYL-1,2,3,4,6,7,12,12B ALPHA-OCTAHYDROINDOLO/2,3-A/ QUINOLIZINE PREPARATION

摘要

The invention relates to the new (-)-1 beta -ethyl-1 alpha -hydroxymethyl-1,2, 3,4,6,7,12,12b alpha -octa-hydroindolo[2,3-a] quinolizine of the formula (I) IMAGE (I) and acid addition salts thereof. According to another aspect of the invention there is provided a process for the preparation of the compound of formula (I) and acid addition salts thereof by resolution of the corresponding racemic compound and optionally by subsequent hydrolysis and/or salt formation. The compound of formula (I) shows a remarkable peripheral vasodilating and antihypoxial activity. Pharmaceutical compositions comprising it as active ingredient are also within the scope of the invention.