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Sulfo-adenosyl-L-METHIONINSALTE, process for the preparation thereof and pharmaceutical composition containing one or more such salts
Sulfo-adenosyl-L-METHIONINSALTE, process for the preparation thereof and pharmaceutical composition containing one or more such salts
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机译:磺基-腺苷-L-甲硫氨酸酯,其制备方法和包含一种或多种此类盐的药物组合物
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摘要
This invention relates to new stable sulpho-adenosyl-L-methionine (SAMe) salts and the relative production process. Said salts have the following general formula: SAMe.nR(O)m(SO3H)p (I) where m can be zero or 1; n is 1.5 when p is 2, and is 3 when p is 1; R is chosen from the group consisting of alkyl, phenylalkyl and carboxyalkyl, in which the linear or branched alkyl chain contains from 8 to 18 carbon atoms. In particular, the salts according to the present invention are SAMe salts of sulphonic acids, or of sulphuric acid esters, or of dioctylsulphosuccinic acid, which fall within formula (I). The process for producing said salts consists of: a) enriching the starting yeast with SAMe; b) lysing the cells and recovering an aqueous solution rich in SAMe (cell lysate); c) purifying the lysate by ultrafiltration; d) precipitating the SAMe by treatment with one of the aforesaid acids or esters; e) separating the precipitated product, washing it and drying it under vacuum.
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