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METHOD FOR PRODUCING A SOLUTION OF A TECHNETIUM-LABELLED ANTIBODY FRAGMENT AND A KIT FOR RADIOLABELLING AN ANTIBODY FRAGMENT
METHOD FOR PRODUCING A SOLUTION OF A TECHNETIUM-LABELLED ANTIBODY FRAGMENT AND A KIT FOR RADIOLABELLING AN ANTIBODY FRAGMENT
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机译:LAB标记的抗体片段的制备方法和放射性标记抗体片段的试剂盒的制备方法
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摘要
A rapid and quantitative method for producing a sterile, injectable solution of Tc-99m-labeled monovalent antibody fragment comprises the step of mixing a sterile solution containing a monovalent antibody fragment having at least one free sulfhydryl group, stannous chloride and excess tartrate, at mildly acidic pH, or a sucrose-stabilized lyophilizate of such solution, with a sterile solution of Tc-99m-pertechnetate, whereby substantially quantitative labeling of the antibody fragment with Tc-99m is effected in about 5 minutes at ambient temperature, the resultant sterile solution of Tc-99m-labeled monovalent antibody fragment being suitable for immediate injection into a patient for radioimmunodetection.
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