method for preparation of 6 or 7, place, double substituted 6 - 7 - acylamino respectively acylamino penicillins, cephalosporins,and method for preparation of pharmaceutical preparations with antibacterial effect.

摘要

A process is provided which yields derivatives of cephalosporins and penicillins. The process starts with 7-acylaminocephalosporin, or 6-acylaminopenicillin, then the latter compounds are treated with an organolithium compound, followed with t-butyl-hypochlorite. Finally, a defined reagent is added yielding a side chain on the carbon adjacent to the amino-nitrogen. Novel intermediate compounds are also described. The end compounds prepared are active against both gram-positive and gram-negative bacteria.