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9 - amino - 1,2,3,4 - tetrahydroacridin 1 oil and related compounds, processes for their manufacture and use as medicine.
9 - amino - 1,2,3,4 - tetrahydroacridin 1 oil and related compounds, processes for their manufacture and use as medicine.
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机译:9-氨基-1,2,3,4-四氢ac啶1油和相关化合物,其制备方法和用作药物的方法。
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摘要
There are disclosed compounds having the formula for CHEM wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR2 where R2 is loweralkyl, or NR3R4 where R3 and R4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C=O or CR5OH where R5 is hydrogen or loweralkyl; Z is CH2 or C=CR6R7 where R6 and R7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR5=CH where CR5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.
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