DEPOLYMERIZED HEXOSAMINOGLUCAN SULFATES ENDOWED WITH AN ANTITHROMBOTIC, FIBRINOLYTIC, ANTIINFLAMMATORY ACTIVITY, THEIR PROCESS OF PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS

摘要

DEPOLYMERIZED HEXOSAMINOGLUCAN SULFATES ENDOWED WITH ANANTITHROMBOTIC, FIBRINOLYTIC, ANTIINFLAMMATORY ACTIVITY,THEIR PROCESS OF PREPARATION AND RELATED PHARMACEUTICALCOMPOSITIONSAbstract:The present invention concerns a process for thepreparation of oligosaccharides by a controlled chemicaldepolymerization of natural polysaccharides, such as hepa-rins, heparan sulfates, dermatan sulfates, chondroitinsul-fates, hyaluronic acid, by a radicalic reaction in anaqueous solution, at a temperature ranging between 20° and70°C, in the presence of a catalyst selected in the groupconsisting of Cu++, Fe++, Cr+++, Cr2O7-- as well as theresulting oligosaccharides and their related pharmaceuti-cal compositions.