PROCESS FOR THE PREPARATION OF STABILIZED ISOSORBIDE- 5-MONONITRATE TABLETS, BEING ALSO OF SUSTAINED RELEASE, AND FORMULATIONS THUS OBTAINED

摘要

ABSTRACTThe present invention relates to obtaining isosorbide-5-mononitrate tablets, beingalso of retard form, which are stable in time. Such embodiment is now possible after thediscovery of the stabilizing activity of the polyvinylpyrrolidone with respect to theisosorbide-5-mononitrate with which it forms a solid solution. The use of PVP is essentialso that the tablets can remain stable in time: the retard effect in turn can be obtainedwith the use of hydroxyalkylcelluloses.