NITROFURANTOIN DOSAGE FORM

摘要

NITROFURANTOIN DOSAGE FORMVikram S. PatelHarry L. WeilesABSTRACTThe invention involves a combination sustained release/rapidrelease pharmaceutical capsule for oral administration of nitrofurantoincomprising, in a capsule shell, a first layer of a first particulatemixture comprising nitrofurantoin, polyvinylpyrrolidone and carboxy-vinylpolymer; and a second layer of a second particulate mixturecomprising macrocrystalline nitrofurantoin.