PROCESS FOR THE TREATMENT OF THE SKIN TO ALLEVIATE SKIN DISEASES ARISING FROM CONTACT SENSITIZATION OR IRRITATION UTILIZING P-SUBSTITUTED PHENOXY ALKANOLS

摘要

72-013 PROCESS FOR THE TREATMENT OF THE SKIN TO ALLEVIATE SKIN DISEASES ARISING FROM CONTACT SENSITIZATION OR IRRITATION UTILIZING p-SUBSTITUTED PHENOXY ALKANOLS Skin diseases are treated by topical application of p-substituted phenoxy alkanols having the structure: I in which: R1 substituted in ortho, meta or para position is selected from hydrogen, halogen, alkyl having from one to six carbon atoms, preferably para-chlorine or para-tertiary-butyl; and bivalent cycloalkylene condensed with the phenyl group at adjacent ring carbons thereof, such as in indane; R2 and R3 are hydrogen or hydroxyl and at least one of R2 and R3 is hydroxyl; and n1, n2 and n3 represent the number of CH2, CHR2 and CH2 groups, respectively, and are numbers within the range from 1 to 10. The topical application to the skin of these compounds jointly with an agent that causes irritation, inflammation or contact sensitization modifies and mitigates such irritation, inflammation and sensitization.