PROCESS FOR PRODUCTION OF PEPTIDYLGLYCINE ALPHA-HYDROXYLATING MONOOXYGENASE AND USE THEREOF

摘要

A process for the production of peptidylglycine alpha -amidating monooxygenase, comprising the steps of: culturing insect cells transfected with a recombinant baculovirus to which a DNA coding for the peptidylglycine alpha -amidating monooxygenase has been incorporated to produce the enzyme, and recovering the enzyme from the culture; and a process for the production of a C-terminal alpha -amidating peptide, comprising converting a C-terminal glycine-extended peptide to a C-terminal alpha -amidating peptide using the enzyme prepared by the above process. IMAGE