首页> 外国专利> Liquid preparation containing living microorganisms, process for preparing it, pelleted product containing living microorganisms and process for preparing it

Liquid preparation containing living microorganisms, process for preparing it, pelleted product containing living microorganisms and process for preparing it

机译:含有活微生物的液体制剂,其制备方法,含有活微生物的粒状产品及其制备方法

摘要

The microorganisms in the preparation are suspended in a liquid oil phase, and the preparation can be stored at room temperature for two years or more without considerable numbers of the microorganisms having died if the microorganisms suspended in the oil phase are enveloped in at least one protective layer which is insoluble in the oil phase and is soluble or swells in water. The protective layer should preferably be solid at room temperature and not degradable by the microorganisms. The preparations are produced by mixing the microorganisms, which have been removed from the culture medium, with an aqueous medium which contains a solution or dispersion of a material of the protective layer which is soluble or swells in water, drying this mixture at least until the material of the protective layer is solid, but preferably completely drying it, and then introducing the dried enveloped microorganisms into the oil phase. The dried microorganisms enveloped in the protective layer can also be mixed with inert solid products and pelleted under pressure at elevated temperatures. These pellets can also be stored at room temperature for several years with retention of the viability of the microorganisms.
机译:将制剂中的微生物悬浮在液体油相中,并且如果将悬浮在油相中的微生物包裹在至少一种保护剂中,则该制剂可以在室温下保存两年或更长时间而不会有大量的微生物死亡。该层不溶于油相,可溶于水或在水中溶胀。保护层应优选在室温下为固体,并且不能被微生物降解。通过将已从培养基中去除的微生物与含有可溶于水或在水中溶胀的保护层材料的溶液或分散液的水性介质混合,将该混合物干燥至少至保护层的材料为固体,但最好将其完全干燥,然后将干燥的包膜微生物引入油相。包封在保护层中的干燥的微生物也可以与惰性固体产物混合,并在升高的温度下在压力下沉淀。这些颗粒也可以在室温下保存数年,同时保持微生物的活力。

著录项

  • 公开/公告号EP0180743B1

    专利类型

  • 公开/公告日1991-11-06

    原文格式PDF

  • 申请/专利权人 CERNITIN S.A.;

    申请/专利号EP19850111734

  • 发明设计人 LEWENSTEIN ARI;

    申请日1985-09-17

  • 分类号C12N1/04;C12N11/04;A61K9/50;A61K35/74;A01N63/00;A23K1/00;

  • 国家 EP

  • 入库时间 2022-08-22 05:54:04

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