New antibiotics, benanomicins A and B and dexylosylbenanomicin B, and production and uses thereof

摘要

Two new antibiotics which are now nominated as benanomicin A and benanomicin B, respectively, are fermentatively produced by the cultivation of a new microorganism, designated as MH193-16F4 strain, of Actinomycetes. Benanomicins A and B each show antifungal activity and are useful as a therapeutic antifungal agent. A new compound, dexylosylbenanomicin B is now produced by chemical conversion of benanomicin B, and this semi-synthetic antibiotic also shows antifungal activity and is useful as a therapeutic antifungal agent. They have the general formula (I) wherein R is a hydroxyl group or an amino group and R¹ is a hydrogen atom or a xylosyl group, provided that when R is the hydroxyl group, R¹ is not the hydrogen atom, and a salt or an ester of the compound of the formula (I).