Etretine-like or related esters of macrolide antibiotics and lincosamide antibiotics, a process for their preparation and pharmaceutical and cosmetical compositions containing them

摘要

Etretinate-type or related esters of macrolides and of lincosamides corresponding to the following formula: …IMAGE… in which:… R denotes a radical derived from a macrolide or from a lincosamide,… R1 denotes a methyl radical,… R2 denotes a hydrogen atom,… or R1 and R2 together form a vinylene (-CH=CH-) radical,… R3 denotes a hydrogen atom or an alkyl radical containing from 1 to 4 carbon atoms,… and Z denotes a divalent radical of formula: …IMAGE… R4 denoting a hydrogen atom or an alkyl radical containing from 1 to 4 carbon atoms,… or of formula: …IMAGE… their isomers, mixtures and salts of the said esters. …??Use in the treatment of various forms of dermatitis, especially in the treatment of acne.