A novel process for the preparation of 2-diazo-3-trisubstituted silyloxy-3-butenoates

摘要

A novel process for preparing 2-diazo-3-trisubstituted silyloxy-3-butenoates, synthons useful in the conversion of 3-substituted-­4-acetoxy azetidinones and penicillin to thienamycin, is provided, comprising the reaction of the appropriate diazo acetoacetate with the substituted silane, base and salt.