A process for obtaining the gangliosides from nervous tissue of mammalians and for the treatment of psychoorganic diseases with said material compositons

摘要

A process for obtaining gangliosides from mammalian nervous tissue, comprises the step of:-(a) extracting the nervous tissue using at least one (C₁-C₄) alcohol and at least one non-polar organic solvent,(b) filtering the mixture and adding water to the filtrate to produce an aqueous alcoholic phase,(c) adsorbing gangliosides present in said aqueous alcoholic phase on an ion exchange material, and then washing the ion exchange material with a ketone,(d) recovering the gangliosides from the ion exchange material using a solvent mixture including water, (C₁-C₄) alcohol(s), organic solvent(s) and alkali(es),(e) purifying the material recovered from the ion exchange material by partition or absorption column chromatography, and(f) recovering the extracted gangliosides from the chromatography column.