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Novel oligopeptides, pharmaceutical composition and food containing the same, and use of oligopeptides
Novel oligopeptides, pharmaceutical composition and food containing the same, and use of oligopeptides
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机译:新型寡肽,药物组合物和包含该寡肽的食品以及寡肽的用途
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L-Tyr-L-Val, L-Leu-L-Tyr, L-Leu-L-Pro, L-Phe-L-Tyr, L-Tyr-L-Arg and its acid addition salts, L-Leu-L-Ser-L-Pro, L-Leu-L-Gln-L-Pro, L-Phe-L-Leu-L-Pro, L-Leu-L-Leu-L-Pro, L-Leu-L-Asn-L-Pro, L-Phe-L-Leu-L-Pro, L-Leu-L-Ala-L-Ala, L-Val-L-Ala-L-Ala, L-Leu-L-Gln-L-Gln, L-Val-L-Ala-L-Tyr, L-Leu-L-Ala-L-Tyr, L-Leu-L-Ser-L-His and its acid addition salts, L-Ile-L-Arg-L-Ala and its acid addition salts, L-Leu-L-Arg-L-Pro and its acid addition salts, and L-Ile-L-Arg-L-Ala-L-Gln-L-Gln and its acid addition salts, derived from a corn protein α-zein, and tripeptides represented by the formula L-( or D- ) Leu-L-Xaa-L-Prowherein Xaa is Gly, Ala, Val, Ile, Thr, Asp, Glu, Lys, Orn, Cys, Met, Phe, Tyr, Trp, His or a hydroxyproline reside, pharmacologically acceptable acid addition salts of the above tripeptides wherein Xaa is Lys, Orn, His or Arg, and pharmacologically acceptable alkali or alkaline earth metal salts, ammonium salts or organic base salts of the tripeptides wherein Xaa is Asp or Glu, have an angiotensin converting enzyme-inhibiting activity.
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机译:L-Tyr-L-Val,L-Leu-L-Tyr,L-Leu-L-Pro,L-Phe-L-Tyr,L-Tyr-L-Arg及其酸加成盐,L-Leu-L -Ser-L-Pro,L-Leu-L-Gln-L-Pro,L-Phe-L-Leu-L-Pro,L-Leu-L-Leu-L-Pro,L-Leu-L-Asn -L-Pro,L-Phe-Leu-L-Pro,L-Leu-L-Ala-L-Ala,L-Val-L-Ala-L-Ala,L-Leu-L-Gln-L -Gln,L-Val-L-Ala-L-Tyr,L-Leu-L-Ala-L-Tyr,L-Leu-L-Ser-L-His及其酸加成盐,L-Ile-L- Arg-L-Ala及其酸加成盐,L-Leu-L-Arg-L-Pro及其酸加成盐,L-Ile-L-Arg-L-Ala-L-Gln-L-Gln及其玉米蛋白α-玉米醇溶蛋白衍生的酸加成盐和下式表示的三肽L-(或D-)Leu-L-X aa Sub> -L-Pro其中X aa Sub>是Gly,Ala,Val,Ile,Thr,Asp,Glu,Lys,Orn,Cys,Met,Phe,Tyr,Trp,His或羟脯氨酸存在的药理上可接受的酸加成盐其中X aa Sub>是Lys,Orn,His或Arg的上述三肽,以及其中X aa 的三肽的可药用碱金属或碱土金属盐,铵盐或有机碱盐Sub>是Asp或Glu,具有血管紧张素转化酶抑制活性。
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