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Derivatized DTPA Complex, Pharmaceutical Formulations Containing the Compound, Uses thereof, and Methods of Making the Same.
Derivatized DTPA Complex, Pharmaceutical Formulations Containing the Compound, Uses thereof, and Methods of Making the Same.
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机译:衍生的DTPA配合物,含有该化合物的药物制剂,其用途及其制备方法。
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摘要
Compounds of the general formula IMAGE in which Z1 and Z2 each represent a hydrogen atom or the radical -(CH2)m-(C6H4)q-(O)k-(CH2)n(C6H4) l-(O)r-R, in which m and n denote the figures 0 - 20, k, l, q and r denote the figures 0 and 1 and R denotes a hydrogen atom, an unsubstituted or OR1-substituted C1-C6-alkyl radical or a CH2COOR1 group where R1 denotes a hydrogen atom, a C1-C6-alkyl radical or a benzyl group, X represents a hydrogen atom and/or a metal ion equivalent of an element of atomic number 21 - 29, 42, 44 or 57 - 83, with the proviso that at least two of the substituents X represent a metal ion equivalent in which one of the substituents Z1 and Z2 represents a hydrogen atom and the other does not represent a hydrogen atom, in which - if n and l each represent the figure 0 - k and r do not simultaneously each denote the figure 1, in which Z1 or Z2 do not represent -CH2-C6H4-O-CH2-COOCH2C6H5 or CH2-C6H4-O-(CH2)5-COOCH2C6H5 and in which -(O)r-R does not represent -OH, and their salts with inorganic and/or organic bases, amino acids or amino acid amides, are useful pharmaceutical agents.
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