process for the production of rechtsdrehenden enantiomers of 1 - pyridyl - 1 - (hydroxy or ethoxy) - ethyl - 4 - (o - methoxyphenyl) piperazine

摘要

A process for the preparation of 1-pyridyl-alkyl-4-aryl piperazines, in the racemic form, of the formula IMAGE (I) in which: the pyridine ring is alpha-, beta-, or gamma-substituted; R=H; CnH2n+1, n being in the range from 1 to 4; R'=H, halogen, CH3, OCH3, in which process: (a) pyridine aldehyde is reacted between -5 DEG C. and 0 DEG C. with (CH3)2S=CH2; (b) the oxirane so obtained is treated with an arylpiperazine; (c) the hydroxyl derivative obtained in (b), after salification with alkaline hydrides or hydrates in a solvent medium is treated with alkylating agents, and the separation of the compounds so obtained into the respective optical antipodes.