use of 2 - amino - 6 - allyl - 5,6,7,8 - tetrahydro in thiazolo (4.5) azepins to manufacture a for the treatment of parkinson's disease. the parkinsonism suitable product.

摘要

2-Amino-6-allyl-5,6, 7,8-tetrahydro- 4H-thiazolo(4,5-d)azepine (I) and its acid addition salts for the treatment of Parkinson's disease or parkinsonism are new. (I) dihydrochloride (B-HT920) is a known selective agonist of presynaptic dopaminergic receptors (e.g. Acta Pharmacol.Toxicol. 1983, 52, 51-56, J.Neural Transmission 1983, 59, 129-137). Biological test results are given in the specification demonstrating that B-HT920 also exerts an agonistic effect on denervated or degenerated post-synaptic dopaminergic structures of the brain and is therefore useful in the treatment of Parkinsonism. Tests described include inhibition of exploratory and stereotyped movement in naive rats, effects on ipsilateral rotation in the rat ibotenic acid model and on contralateral rotation in the 6-OHDA model, and effects on the MPTP Parkinsonism model in the rhesus monkey.