Sepn. material for chromatography - consists of cyclodextrin chemically bonded onto carrier via carbamic acid gps.

摘要

A sepn. material (I) for use in chromatography consists of a carrier and cyclodextrin, chemically bonded on the carrier via carbamic acid gps. (I) can be prepd. by activating cyclodextrin with chloromethanoic acid and then reacting the activated cyclodextrin either (a) with an amino silane which contains at least one further reactive gp. to give the corresp. cyclodextrin silane deriv. and then reacting this with the carrier in a silanising reaction; or (b) directly with a carrier which is modified with amino gps. by a silanising reaction. In each case carbamic acid gps. are formed between the cyclodextrin and the amino gps. The carrier is pref. silica gel. The chloromethanoic acid ester is pref. the p-nitrophenyl or N-succinimide ester. -