Use of medicament containing muscarine agonist - to prevent and treat ventricular arrhythmia, especially acute or malignant arrhythmia

摘要

The medicament contains a muscarine agonist, pref. oxotremorine, metacoline, betancol (or a salt) or pilocarpine, opt. in conjunction with an antiarrhythmic agent, pref. flecainide, encainide, quinidine, procainamide, mexiletine, lidocain, propaphenone or a slat. The muscarine agonist and the antiarrhythmic agent are pref. in separate containers. USE/ADVANTAGE - To prevent or treat malignant or acute ventricular arrhythmia (claimed). The treatment is suitable for patients at risk of sudden death, e.g. those who have suffered a myocardial infarct, or who have dilative cardiopathology or malignant ventricular arrhythmia, especially when associated with a high sympathicus tonus. In an example, arrhythmia was induced in anaesthetised cats by blocking a coronary blood vessel and electrically stimulating the left stellate ganglion. The deg. of arrhythmia was measured on a scale of 0 (no arrhythmia) to 4 (fibrillation). When the cats were given 2.5 micro-g/kg oxotremorine sesquifumarate i.v., the average score fell from 3.2 to 1.7.