New 19 - normal osteoblasts 11beta in position a chain carbon comprising an amide or carbamate function to the # # this, their application as medicinal products and the pharmaceutical compositions containing them,

摘要

The invention relates to the compounds (I): …IMAGE… in which A and B are either …IMAGE… where R2 and R'2 are H or alkyl (C1-4), or …IMAGE… where R3 is H or alkyl (C1-4) or acyl, and… - either R17 and R'17 together form a ketone,… - or R17 is hydroxyl or acyloxy and R'17 represents hydrogen, alkyl, alkenyl or alkynyl, these groups being optionally substituted,… - X represents methylene, arylene, CH2-O or arylenoxy,… - Y represents a single bond or aliphatic chain (C1-18) optionally interrupted by one or more arylene(s) or oxygen(s) or optionally oxidised sulphur(s), the chain optionally terminating in an arylene,… - Z represents a single bond or CH2-O, on the understanding that when Y and Z are a single bond, X cannot be methylene or CH2-O,… -RA and RA' represent hydrogen, alkyl optionally substituted with aryl, alkyl or dialkylamino, hydroxyl, halogen or esterified carboxyl, or RA and RA' form, with the nitrogen, a saturated or unsaturated heterocycle optionally containing one or more other hetero atoms and optionally substituted with an alkyl (C1-4), on the understanding that at least one of RA or RA' is not a hydrogen,… to their preparation, to their use as medicaments, to compositions containing them and to the new intermediates obtained.