Avidin and streptavidin modified water-soluble polymers such as polyacrylamide, and the use thereof in the construction of soluble multivalent macromolecular conjugates

摘要

Avidin and streptavidin modified water-soluble polymers are provided, such modified polymers being exemplified by, but not limited to, water- soluble polyacrylamides being substituted by multiple substituents of avidin or streptavidin. The avidin and streptavidin modified polymers provided, may be stored, and later used to bind biotinylated antibiodies, biotinylated toxins, or biotinylated isotope- labelled proteins, thus producing homo- or heteroconjugates of known composition. A process for the preparation of certain of the avidin or streptavidin modified polymers and conjugates thereof is also provided.