SUBSTITUTED 9H-8-OXO-PYRIMIDO(2,1-F)PURINE-2,4-DIONES, MANUFACTURE AND MEDICINAL COMPOSITION

摘要

The new compounds are compounds of formula (I) CHEM and its tautomer and the pharmaceutically acceptable salts thereof, wherein R1 and R2 are the same or different and are hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, aryl; alkyl substituted by cycloalkyl, aryl or heterocyclic radical; R3 is hydrogen, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, acyloxyalkyl, oxoalkyl, aryl; alkyl substituted by cycloalkyl, cycloalkenyl, aryl, hydroxy, cyano, halo or heterocyclic radical: -alkyl-X-CnH2n-1 wherein X is O,S,S+-O-, SO2 or -N-CpH2p-1; -(CH2)qC(O)NR6R7 or -(CH2) C(O)OR8; R4 is hydrogen, alkyl, aryl, a heterocyclic radical; or alkyl substituted by cycloalkyl aryl or a heterocyclic radical, R5 is hydrogen acyl, or alkyl. These compounds are useful as antiinflammatory agents for treating inflammatory conditions such as arthritis, spondylitis, and tendonitis in mammals.